A simple diagnostic procedure, followed by an interventional radiology treatment known as fallopian tube recanalization, could allow a high percentage of women struggling with infertility from blocked fallopian tubes to conceive with less involved or, in some cases, no further invasive fertility procedures.

Researchers at the University of British Columbia (Vancouver, BC, Canada) studied cases from 2015 to 2021 involving 956 women with infertility who previously had been diagnosed as having one or both fallopian tubes blocked based on the standard diagnostic procedure used to assess the openness of fallopian tubes, known as hysterosalpingogram (HSG). The women then underwent a selective salpingography to confirm their HSG diagnosis and, if needed, underwent fallopian tube recanalization. In many cases, researchers said, the purported blockage was only a piece of mucus that was easily removed.

Selective salpingography uses X-ray guidance to insert a tiny catheter through the cervix and into the opening of the fallopian tubes. A contrast dye is then injected to assess whether the tubes are open or blocked. The interventional radiologist, in many cases, is then able to perform recanalization which opens the tube using a fine guidewire. The procedure is performed as an outpatient under light sedation and typically takes under 30 minutes.

In the study, selective salpingography showed that nearly one in four (23.8%) had been mistakenly told they had one or both blocked fallopian tubes. Of those with a blockage, over half (56.7%) were unblocked using a fine wire in the fallopian recanalization process, researchers said. In sum, 80.5% of women in the study who had previously been told they had tubal blockages left the same day with both fallopian tubes open after a simple outpatient procedure. In an additional 15.9% a more precise diagnosis of significant tubal disease was made that in many cases, potentially altered treatment options. The research suggests that selective salpingography should be offered more broadly in assessing and treating female infertility.

“This procedure and treatment can help women make an informed decision about infertility treatments. And for many, it can actually give them the chance to conceive naturally,” said Lindsay Machan, MD, associate professor in the Department of Radiology at the University of British Columbia and a lead author of the study. “Fertility treatments can be expensive and out of reach for many women. Infertility is also an emotional, often heart-breaking journey, so having this diagnostic procedure and treatment available could be life-changing.” 

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